cell to cell adhesion signaling
| PAG Title | cell to cell adhesion signaling |
| PAG ID | WAG000833 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Interactions between cells responsible for cell to cell adhesion also can communicate sigls into the cellular interior, often involving interactions with cytoskeletal elements to produce changes in cell motility, migration, proliferation and shape. The cadherins are cell surface adhesion molecules that help form tight junctions between cells such as formation of epithelial cell layers. E-cadherin ictivation has been implicated in cancer development. In addition to mediating adhesion with other cells, cadherins transduce sigls into cells through interactions with the catenins. Catenins probably affect actin cytoskeletal function through interactions with proteins like actinin and vinculin. Catenins also probably trigger changes in cell shape and motility with sigls through the Rho small GTPases. Another important cell adhesion molecule is CD-31, or PECAM-1, involved in the formation of junctions between endothelial cells, cell migration, migration of lymphocytes, and regulation of lymphocyte activation. Src phosphorylates PECAM-1 on tyrosine residues causing SHP-2 association with PECAM-1. Paxillin acts as an adaptor protein between proteins involved in adhesion sigling like FAK and src and cytoskeletal elements. In addition to sigls created by adhesion molecules to alter cellular responses, other sigling pathways can alter adhesion through components of the focal adhesion complex. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,458 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG000833 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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